WHAT IS IT?

Under some circumstances a rapid onset of immunological protection is preferred, e.g. in an emergency situation or pandemic. Some of our studies have clearly indicated that certain treatments can result in the development of a protective immune response over a more rapid timeframe than is usually the case. In the example shown protective levels of haemagglutination inhibiting antibodies (>50) arose between 7 and 14 days post vaccination as opposed to the normal > 21days.

BENEFITS

Accelerating the production of a protective immune response (from a single inoculation) could have dramatic implications in the curtailment of disease progression. There would be a lower likelihood of infection of a vaccinated individual during the period immediately after vaccination and this would limit the person to person spread.

In the example of influenza above, after vaccination there is a period of 3-4 weeks where the subject is able to become infected, as the immune reaction is still not robust enough (HAI >50). Several vaccination schedules require one or more booster doses of vaccine to generate an immune response high enough to protect against infection. If the booster is missed or ineffective, the subject would remain susceptible to infection.

Demonstration of rapid onset of immunity using Influenza vaccine.